abstract：:Low concentrations of oxidized low density lipoprotein (OxLDL) are cytoprotective for phagocytes, although the underlying mechanisms remain unclear. We investigated signaling pathways used by OxLDL to attenuate apoptosis in monocytic cells. OxLDL at 25-50 mug/ml inhibited staurosporine-induced apoptosis in THP-1 cells...

journal_title：Journal of lipid research

authors： Namgaladze D,Kollas A,Brüne B

更新日期：2008-01-01 00:00:00

abstract：:Whereas antibipolar drug administration to rats reduces brain arachidonic acid turnover, excessive N-methyl-d-aspartate (NMDA) signaling is thought to contribute to bipolar disorder symptoms and may increase arachidonic acid turnover in rat brain phospholipids. To determine whether chronic NMDA would increase brain ar...

journal_title：Journal of lipid research

authors： Lee HJ,Rao JS,Chang L,Rapoport SI,Bazinet RP

更新日期：2008-01-01 00:00:00

abstract：:The skin surface represents our interface with the external environment, and as such, is our first line of defense against microbial colonization and infection. Lipids at the skin surface are thought to underlie at least part of an antimicrobial barrier. Some of these lipids are synthesized in the epidermis and are ca...

journal_title：Journal of lipid research

authors： Drake DR,Brogden KA,Dawson DV,Wertz PW

更新日期：2008-01-01 00:00:00

abstract：:LDL receptor-null (LDLR(-/-)) mice on a Western diet (WD) develop endothelial dysfunction and atherosclerosis, which are improved by the apolipoprotein A-I (apoA-I) mimetic peptide D-4F. Focusing on the kidney, LDLR(-/-)mice were fed a WD with D-4F or the inactive control peptide scrambled D-4F (ScD-4F) added to their...

journal_title：Journal of lipid research

authors： Buga GM,Frank JS,Mottino GA,Hakhamian A,Narasimha A,Watson AD,Yekta B,Navab M,Reddy ST,Anantharamaiah GM,Fogelman AM

更新日期：2008-01-01 00:00:00

abstract：:A variety of methods are currently used to analyze HL and LPL activities in mice. In search of a simple methodology, we analyzed mouse preheparin and postheparin plasma LPL and HL activities using specific polyclonal antibodies raised in rabbit against rat HL (anti-HL) and in goat against rat LPL (anti-LPL). As an alt...

journal_title：Journal of lipid research

authors： Dallinga-Thie GM,Zonneveld-de Boer AJ,van Vark-van der Zee LC,van Haperen R,van Gent T,Jansen H,De Crom R,van Tol A

更新日期：2007-12-01 00:00:00

abstract：:Black tea is one of the world's most popular beverages, and its health-promoting effects have been intensively investigated. The antiobesity and hypolipidemic effects of black tea have attracted increasing interest, but the mechanisms underlying these phenomena remain unclear. In the present study, the black tea major...

journal_title：Journal of lipid research

authors： Lin CL,Huang HC,Lin JK

更新日期：2007-11-01 00:00:00

abstract：:The fatty acid transport protein (FATP) Fat1p in the yeast Saccharomyces cerevisiae functions in concert with acyl-coenzyme A synthetase (ACSL; either Faa1p or Faa4p) in vectorial acylation, which couples the transport of exogenous fatty acids with activation to CoA thioesters. To further define the role of Fat1p in t...

journal_title：Journal of lipid research

authors： Obermeyer T,Fraisl P,DiRusso CC,Black PN

更新日期：2007-11-01 00:00:00

abstract：:CTP:phosphoethanolamine cytidylyltransferase (Pcyt2) catalyzes the rate-controlling reaction of the CDP-ethanolamine (Kennedy) pathway. We have previously established that Pcyt2 is encoded by a single gene that can be alternatively spliced from an internal exon into two transcripts, designated Pcyt2alpha and Pcyt2beta...

journal_title：Journal of lipid research

authors： Tie A,Bakovic M

更新日期：2007-10-01 00:00:00

abstract：:Serum amyloid P (SAP) is a common component of human amyloid deposits and has been identified in atherosclerotic lesions. We investigated the extent of the colocalization of SAP with apolipoprotein A-I (apoA-I), apoB, apoC-II, and apoE in human coronary arteries and explored potential roles for SAP in these regions, s...

journal_title：Journal of lipid research

authors： Stewart CR,Haw A 3rd,Lopez R,McDonald TO,Callaghan JM,McConville MJ,Moore KJ,Howlett GJ,O'Brien KD

更新日期：2007-10-01 00:00:00

abstract：:Here, we present an improved method for sensitive profiling of lipids in a single high-performance liquid chromatography-electrospray ionization-quadrupole time of flight mass spectrometry experiment. The approach consists of i) sensitive isocratic elution, which takes advantage of C18 column material that is resistan...

journal_title：Journal of lipid research

authors： Shui G,Bendt AK,Pethe K,Dick T,Wenk MR

更新日期：2007-09-01 00:00:00

abstract：:Conjugated linoleic acid (CLA), a mixture of isomers of linoleic acid, has previously been shown to be able to decrease porcine subcutaneous (SC) adipose tissue levels while increasing the count of intramuscular (IM) adipose tissue in vivo. However, the underlying mechanisms through which it acts are poorly understood...

journal_title：Journal of lipid research

authors： Zhou X,Li D,Yin J,Ni J,Dong B,Zhang J,Du M

更新日期：2007-08-01 00:00:00

abstract：:Recombinant human pancreatic lipase-related protein 2 (rHPLRP2) was produced in the protease A-deficient yeast Pichia pastoris. A major protein with a molecular mass of 50 kDa was purified from the culture medium using SP-Sepharose and Mono Q chromatography. The protein was found to be highly sensitive to the proteoly...

journal_title：Journal of lipid research

authors： Eydoux C,De Caro J,Ferrato F,Boullanger P,Lafont D,Laugier R,Carrière F,De Caro A

更新日期：2007-07-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor alpha (PPAR alpha) is a transcriptional regulator of the expression of mitochondrial thioesterase I (MTE-I) and uncoupling protein 3 (UCP3), which are induced in the heart at the mRNA level in response to diabetes. Little is known about the regulation of protein expression of...

journal_title：Journal of lipid research

authors： King KL,Young ME,Kerner J,Huang H,O'Shea KM,Alexson SE,Hoppel CL,Stanley WC

更新日期：2007-07-01 00:00:00

abstract：:This review focuses on adipose tissue biology and introduces the concept of adipose tissue plasticity and expandability as key determinants of obesity-associated metabolic dysregulation. This concept is fundamental to our understanding of adipose tissue as a dynamic organ at the center of nutritional adaptation. Here,...

journal_title：Journal of lipid research

authors： Sethi JK,Vidal-Puig AJ

更新日期：2007-06-01 00:00:00

abstract：:Rates of conversion of alpha-linolenic acid (alpha-LNA, 18:3n-3) to docosahexaenoic acid (DHA, 22:6n-3) by the mammalian brain and the brain's ability to upregulate these rates during dietary deprivation of n-3 polyunsaturated fatty acids (PUFAs) are unknown. To answer these questions, we measured conversion coefficie...

journal_title：Journal of lipid research

authors： Igarashi M,DeMar JC Jr,Ma K,Chang L,Bell JM,Rapoport SI

更新日期：2007-05-01 00:00:00

abstract：:The genus Acinetobacter is composed of ubiquitous, generally nonpathogen environmental bacteria. Interest concerning these microorganisms has increased during the last 30 years, because some strains, belonging to the so-called A. baumannii-A. calcoaceticus complex, have been implicated in some severe pathological stat...

journal_title：Journal of lipid research

authors： Leone S,Sturiale L,Pessione E,Mazzoli R,Giunta C,Lanzetta R,Garozzo D,Molinaro A,Parrilli M

更新日期：2007-05-01 00:00:00

abstract：:The recent insight that inflammation contributes to the development of atherosclerosis and type 2 diabetes mellitus constitutes a major breakthrough in understanding the mechanisms underlying these conditions. In addition, it opens the way for new therapeutic approaches that might eventually decrease the prevalence of...

journal_title：Journal of lipid research

authors： Popa C,Netea MG,van Riel PL,van der Meer JW,Stalenhoef AF

更新日期：2007-04-01 00:00:00

abstract：:Niemann-Pick type C (NPC) disease is a multisystem disorder resulting from mutations in the NPC1 gene that encodes a protein involved in intracellular cholesterol trafficking. Significant liver dysfunction is frequently seen in patients with this disease. The current studies used npc1 mutant mice to investigate the as...

journal_title：Journal of lipid research

authors： Beltroy EP,Liu B,Dietschy JM,Turley SD

更新日期：2007-04-01 00:00:00

abstract：:Tissue-specific regulation of LPL has been widely studied in rats. Previous studies reported that in vivo administration of adrenaline and acute stress cause an increase in plasma LPL activity coinciding with a decrease in white adipose tissue (WAT) LPL activity. We studied the speed of LPL activity changes during 30 ...

journal_title：Journal of lipid research

authors： Casanovas A,Parramon N,de la Cruz F,Andrés O,Terencio J,López-Tejero MD,Llobera M

更新日期：2007-04-01 00:00:00

abstract：:Previous in vitro studies have revealed that oxidized low density lipoprotein (OxLDL) has negative effects on the proliferation and activity of endothelial progenitor cells (EPCs). Here, we evaluated the effect of OxLDL on the therapeutic potential of EPCs in ischemia-induced neovascularization. EPCs derived from mobi...

journal_title：Journal of lipid research

authors： Zhou B,Ma FX,Liu PX,Fang ZH,Wang SL,Han ZB,Poon MC,Han ZC

更新日期：2007-03-01 00:00:00

abstract：:The genetic variability of apolipoprotein E (apoE) influences plasma lipoprotein levels, and allele frequencies differ between African Americans and Caucasians. As African Americans have higher lipoprotein [a] (Lp[a]) levels than Caucasians, we investigated the effects of the apoE gene on allele-specific apolipoprotei...

journal_title：Journal of lipid research

authors： Anuurad E,Lu G,Rubin J,Pearson TA,Berglund L

更新日期：2007-03-01 00:00:00

abstract：:Endothelial lipase (EL) has been shown to be a critical determinant for high density lipoprotein cholesterol levels in vivo; therefore, assays that measure EL activity have become important for the discovery of small molecule inhibitors that specifically target EL. Here, we describe fluorescent Bodipy-labeled substrat...

journal_title：Journal of lipid research

authors： Mitnaul LJ,Tian J,Burton C,Lam MH,Zhu Y,Olson SH,Schneeweis JE,Zuck P,Pandit S,Anderson M,Maletic MM,Waddell ST,Wright SD,Sparrow CP,Lund EG

更新日期：2007-02-01 00:00:00

abstract：:The ceramide (Cer) and sphingomyelin (SM) species of cultured differentiated rat cerebellar granule cells and human fibroblasts were characterized by electrospray ionization-mass spectrometry. We identified 35 different species of Cer and 18 species of SM in human fibroblasts, and 35 different species of Cer and 9 spe...

journal_title：Journal of lipid research

authors： Valsecchi M,Mauri L,Casellato R,Prioni S,Loberto N,Prinetti A,Chigorno V,Sonnino S

更新日期：2007-02-01 00:00:00

abstract：:We previously reported that liver-specific overexpression of ABCG5/G8 in mice is not atheroprotective, suggesting that increased biliary cholesterol secretion must be coupled with decreased intestinal cholesterol absorption to increase net sterol loss from the body and reduce atherosclerosis. To evaluate this hypothes...

journal_title：Journal of lipid research

authors： Basso F,Freeman LA,Ko C,Joyce C,Amar MJ,Shamburek RD,Tansey T,Thomas F,Wu J,Paigen B,Remaley AT,Santamarina-Fojo S,Brewer HB Jr

更新日期：2007-01-01 00:00:00

abstract：:Three colipases were purified from pancreas of two birds (ostrich and turkey) and one mammal (dromedary). After acidic and/or heat treatment and precipitation by sulfate ammonium and then ethanol, cofactors were purified by Sephadex G-50 gel filtration followed by ion-exchange chromatography first on Mono S and then o...

journal_title：Journal of lipid research

authors： Ben Bacha A,Frikha F,Djemal I,Fendri A,Miled N,Gargouri Y,Mejdoub H

更新日期：2006-12-01 00:00:00

abstract：:Diseases such as obesity, diabetes, and atherosclerosis result from multiple genetic and environmental factors, and importantly, interactions between genetic and environmental factors. Identifying susceptibility genes for these diseases using genetic and genomic technologies is accelerating, and the expectation over t...

journal_title：Journal of lipid research

authors： Schadt EE,Lum PY

更新日期：2006-12-01 00:00:00

abstract：:The aim of this study was to investigate the extent to which inflammation is linked with plasma endothelial lipase (EL) concentrations among healthy sedentary men. Plasma C-reactive protein (CRP) concentrations were measured with a highly sensitive commercial immunoassay, plasma interleukin-6 (IL-6) concentrations wer...

journal_title：Journal of lipid research

authors： Paradis ME,Badellino KO,Rader DJ,Deshaies Y,Couture P,Archer WR,Bergeron N,Lamarche B

更新日期：2006-12-01 00:00:00

abstract：:Scavenger receptor class B type I (SR-BI) mediates the selective uptake of HDL cholesteryl esters (CEs) and facilitates the efflux of unesterified cholesterol. SR-BI expression in macrophages presumably plays a role in atherosclerosis. The role of SR-BI for selective CE uptake and cholesterol efflux in macrophages was...

journal_title：Journal of lipid research

authors： Brundert M,Heeren J,Bahar-Bayansar M,Ewert A,Moore KJ,Rinninger F

更新日期：2006-11-01 00:00:00

abstract：:Acyl-coenzyme A:diacylglycerol transferase (DGAT), fatty acid synthetase (FAS), and LPL are three enzymes important in adipose tissue triglyceride accumulation. To study the relationship of DGAT1, FAS, and LPL with insulin, we examined adipose mRNA expression of these genes in subjects with a wide range of insulin sen...

journal_title：Journal of lipid research

authors： Ranganathan G,Unal R,Pokrovskaya I,Yao-Borengasser A,Phanavanh B,Lecka-Czernik B,Rasouli N,Kern PA

更新日期：2006-11-01 00:00:00

abstract：:Serum paraoxonase (PON1) is a HDL-associated enzyme exhibiting potentially antiatherogenic properties. Here, we examined the common PON1-192R/Q human polymorphism. Despite numerous studies, the effect of this polymorphism on the antiatherogenic potential of PON1 is yet unresolved. Our structural model suggests that am...

journal_title：Journal of lipid research

authors： Gaidukov L,Rosenblat M,Aviram M,Tawfik DS

更新日期：2006-11-01 00:00:00

abstract：:Achilles tendon xanthomas are associated with increased cardiovascular risk in patients with familial hypercholesterolemia (FH). Oxidized low density lipoprotein (OxLDL), the antibodies against OxLDL, and the LDL-associated phospholipase A(2) (Lp-PLA(2)) may play important roles in atherogenesis. We investigated the p...

journal_title：Journal of lipid research

authors： Tsouli SG,Kiortsis DN,Lourida ES,Xydis V,Tsironis LD,Argyropoulou MI,Elisaf M,Tselepis AD

更新日期：2006-10-01 00:00:00

abstract：:The reversibility and regression of histological and biochemical findings in a mouse model of Gaucher disease (4L/PS-NA) was evaluated using a liver-enriched activator protein promoter control of a tetracycline-controlled transcriptional activation-responsive human acid beta-glucosidase (hGCase) transgenic system. 4L/...

journal_title：Journal of lipid research

authors： Sun Y,Quinn B,Xu YH,Leonova T,Witte DP,Grabowski GA

更新日期：2006-10-01 00:00:00

abstract：:The acute-phase response (APR) leads to alterations in lipid metabolism and type II nuclear hormone receptors, which regulate lipid metabolism, are suppressed, in liver, heart, and kidney. Here, we examine the effect of the APR in adipose tissue. In mice, lipopolysaccharide produces a rapid, marked decrease in mRNA le...

journal_title：Journal of lipid research

authors： Lu B,Moser AH,Shigenaga JK,Feingold KR,Grunfeld C

更新日期：2006-10-01 00:00:00

abstract：:Increased plasma concentrations of apolipoprotein A-IV (apoA-IV) in chronic renal disease suggest a metabolic role of the kidney for this antiatherogenic protein. Therefore, we investigated patients with various forms of proteinuria and found increased serum concentrations of apoA-IV in 124 nephrotic patients compared...

journal_title：Journal of lipid research

authors： Lingenhel A,Lhotta K,Neyer U,Heid IM,Rantner B,Kronenberg MF,König P,von Eckardstein A,Schober M,Dieplinger H,Kronenberg F

更新日期：2006-09-01 00:00:00

abstract：:Distinct isoforms of long-chain acyl-CoA synthetases (ACSLs) may partition fatty acids toward specific metabolic cellular pathways. For each of the five members of the rat ACSL family, we analyzed tissue mRNA distributions, and we correlated the mRNA, protein, and activity of ACSL1 and ACSL4 after fasting and refeedin...

journal_title：Journal of lipid research

authors： Mashek DG,Li LO,Coleman RA

更新日期：2006-09-01 00:00:00

abstract：:Fatty acid elongases and desaturases play an important role in hepatic and whole body lipid composition. We examined the role that key transcription factors played in the control of hepatic elongase and desaturase expression. Studies with peroxisome proliferator-activated receptor alpha (PPARalpha)-deficient mice esta...

journal_title：Journal of lipid research

authors： Wang Y,Botolin D,Xu J,Christian B,Mitchell E,Jayaprakasam B,Nair MG,Peters JM,Busik JV,Olson LK,Jump DB

更新日期：2006-09-01 00:00:00

abstract：:Isotopic measurement of biosynthetic rates of lipids in VLDL particles has long posed difficult technical problems. In this review, key methodologic issues and recent technical advances are discussed. A common problem for all biosynthetic measurements is the requirement to measure isotopic labeling of the true intrace...

journal_title：Journal of lipid research

authors： Parks EJ,Hellerstein MK

更新日期：2006-08-01 00:00:00

abstract：:In vitro, -polylysine (EPL) strongly inhibited the hydrolysis of trioleoylglycerol emulsified with phosphatidylcholine (PC) and taurocholate by either pancreatic lipase or carboxylester lipase. The EPL concentration required for 50% inhibition of pancreatic lipase, 0.12 microM, was eight times lower than the concentra...

journal_title：Journal of lipid research

authors： Tsujita T,Takaichi H,Takaku T,Aoyama S,Hiraki J

更新日期：2006-08-01 00:00:00

abstract：:Vitamin A (VA) is stored in tissues predominantly as retinyl esters (REs), which provide substrate for the production of bioactive retinoids. Retinoic acid (RA), a principal metabolite, has been shown to induce postnatal lung development. To better understand lung RE storage, we compared VA (given as retinyl palmitate...

journal_title：Journal of lipid research

authors： Ross AC,Ambalavanan N,Zolfaghari R,Li NQ

更新日期：2006-08-01 00:00:00

abstract：:In vitro experiments have demonstrated that exogenous phospholipid transfer protein (PLTP), i.e. purified PLTP added to macrophage cultures, influences ABCA1-mediated cholesterol efflux from macrophages to HDL. To investigate whether PLTP produced by the macrophages (i.e., endogenous PLTP) is also part of this process...

journal_title：Journal of lipid research

authors： Lee-Rueckert M,Vikstedt R,Metso J,Ehnholm C,Kovanen PT,Jauhiainen M

更新日期：2006-08-01 00:00:00